I began thinking about how place affects the mystery and my first thought was about Ellis Peters and her books about Cadfael, a monk who lived in the 1100s in Shrewsbury, England in the monastery of Saints Peter and Paul. Could Cadfael have lived anywhere else?
Then there's Donna Leon's Commissario Guido Brunetti who lives in Venice, well respected and well-fed by a loving wife. Where else but Venice?
Tony Hillerman's mysteries take place in the southwest amongst the Navajo tribes. Here Lieutenant Joe Leaphorn and Officer Jim Chee solve crimes and keep criminal behavior in check. the land was made for Hillerman's mysteries.
Mention Oxford, England--the fictional Oxford England and the reader is enthralled with Inspector Morse and his fictional heir, Inspector Lewis. Walk around Oxford and you'll find fans of the series wandering around looking for the places where they solved crimes usually committed by Professors and students.
What mysteries and authors and places can you suggest?